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The port facilities are located on KY-94, with other access routes via KY-125, KY-166, and KY-309. The Julian Carroll Purchase Parkway is accessible in the City of Fulton. Bridges across the Mississippi River are located approximately 41 miles to the north near Cairo, IL and to the south near Dyersburg, TN. There is ferry service crossing the Mississippi River in Hickman, the Dorena-Hickman Ferry.

Rail service at the port is provided by a short line railroad, the TennKen Railroad Company. The rail line is the former Illinois Central branch line from Dyersburg, TN to Hickman, KY, owned by a local non-profit corporation, the Hickman River City Development Corporation, and currently operated by a third party short line operator from out of state. The Class I connection in Dyersburg, TN is with the Canadian National Railway. All rail tracks within the confines of the port are owned and maintained by the port.